Crosby, wearing a facemask as extra protection after getting hit in the head by a shot over the weekend, added two assists to boost his career point total against the Flyers to 102 as the Penguins rolled to a rare lopsided victory over their cross-state rivals.
Jared McCann, Justin Schultz, Zach Aston-Reese, Jake Guentzel and Dominik Kahun also scored for Pittsburgh. Matt Murray stopped 29 shots to win for the sixth time in his last seven starts.
Oskar Lindblom got his sixth goal for the Flyers, but Philadelphia was simply overwhelmed by the Penguins during a first-period onslaught in which Pittsburgh beat Brian Elliott four times in just more than six minutes.